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KMID : 0616120100410020097
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 2 p.97 ~ p.102
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Inhibition of IL-6 Production in TNF-a Stimulated MG-63 by the Triterpenoids Isolated from Aucuba japonica
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Jin Qing-Long
Woo Eun-Rhan
Choi Eun-Jin
Shin Ji-Eun
Jin Hong-Guang
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Abstract
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Six triterpenoid compounds, friedelin (1), 3a-hydroxy-2-friedelanone (2), canophyllol (3), oleanolic aldehyde acetate (4), ursolic acid (5), and pachysandiol A (6) were isolated from the methylene chloride soluble fraction of the roots of A. japonica. The chemical structures of compounds 1-6 were determined by the basis of physico-chemical properties and spectroscopic methods such as 1D and 2D NMR. These compounds were isolated from this plant for the first time. For the isolated compounds (1-3), the inhibitory effect of IL-6 production in TNF-a stimulated MG-63 was examined. Among the isolates, 3a-hydroxy-2-friedelanone (2) showed potent inhibitory effect on IL-6 production in TNF-a stimulated MG-63.
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KEYWORD
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Aucuba japonica, Cornaceae, Triterpenoid, IL-6 inhibitory effect
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